Homozygote A 2 allele of Interleukin 4 is Associated with Poor Outcome of Traumatic Brain Injury in Sudanese Patients

Background: Traumatic brain injury (TBI) is a major global health concern, as the most common cause of death in the developed countries. Several studies investigated IL-4 alleles in different cases. The rare alleles of these polymorphisms were found to be associated with high IL-4 expression. Aims of the study: In the present study we aimed to investigate IL-4 gene and some biochemical profile in 51 Sudanese of TBI patients and compare between the outcome and il-4 alleles. Material and methods: This is a cross sectional study that had been conducted in the National Center of Neurological Sciences, during January 2016 to March 2016. Results: molecular screening of 51 TBI patients specimens showed that, the most common allele of IL-4 VNTR was A1/A1 allele in37.3%. Calcium results showed that 72.5% of the patients were present with hypocalcaemia (< 8.5 mg/dl). Conclusion: the most common allele of IL-4 among TBI patients was A1/A2 allele, and hypocalcaemia was detected in 72% of the patients.