Characterization of p 38 MAPK isoforms for drug resistance study using systems biology approach

Huiming Peng, Tao Peng,Jianguo Wen,David A. Engler,Risë K. Matsunami,Jing Su, Le Zhang,Chung-Che Chang, Xiaobo Zhou

semanticscholar（2014）

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摘要

Motivation: p38 mitogen-activated protein kinase activation plays an important role in resistance to chemotherapeutic cytotoxic drugs in treating multiple myeloma (MM). However, how the p38 mitogenactivated protein kinase signaling pathway is involved in drug resistance, in particular the roles that the various p38 isoforms play, remains

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