Serum concentration and pharmacokinetics of tobramycin in intravenous drip infusion

out of seven cases,in only one out of eleven cases when intravenous drip infusion of 3 mg/kg was made for one hour,and in only two out of five cases when intravenous drip infusion of 3 mg/kg was made for 30 minutes. Biological half-life in neonates was more extended than in adults and the distribution volume and serum clearance in neonates were two or three times greater than in adults. By intravenous drip infusion of tobramycin on neonates,a significant correlation was observed between elimination rate constant and distribution volume and between elimina-