This is a repository copy of Drug resistance without drug selection: polymorphism in leuS confers reduced susceptibility 1 to GSK2251052 in a clinical isolate of Staphylococcus aureus

Arya Gupta, Carmine Monteferrante,Dace Rasina,Gundars Leitis,Christopher P Randall,Jennifer H Tomlinson,Aigars Jirgensons,Wil HF Goessens,John P Hays

semanticscholar（2018）

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Abstract

14 GSK2251052 is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS) that has 15 been evaluated in Phase II clinical trials. Here we report the identification of a clinical isolate of 16 Staphylococcus aureus that exhibits reduced susceptibility to GSK2251052 without prior exposure to 17 the compound, and demonstrate that this phenotype is attributable to a single amino acid 18 polymorphism (P329) within the editing domain of LeuRS. 19

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