PROTEOSTASIS UBE 2 O remodels the proteome during terminal erythroid differentiation

INTRODUCTION: The reticulocyte–red blood cell transition is a canonical example of terminal differentiation. The mature red blood cell has one of the simplest cellular proteomes known, with hemoglobin remarkably concentrated to ~98%of soluble protein. During reticulocytematuration, the proteome is remodeled through the programmed elimination of most generic constituents of the cell, in parallel with abundant synthesis of cell type–specific proteins such as hemoglobin. Themechanisms that drive rapid turnover of soluble and normally stable proteins in terminally differentiating cells remain largely unclear.