1 atp-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta-cells

1 ATP-CITRATE LYASE REDUCTION MEDIATES PALMITATE-INDUCED APOPTOSIS IN PANCREATIC BETA-CELLS Kwan Yi Chu, Yalin Lin, Alon Hendel, Jerzy E. Kulpa, Roger W. Brownsey, James D. Johnson* From the Laboratory of Molecular Signaling in Diabetes, Diabetes Research Group, Department of Cellular and Physiological Sciences, and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada Running head: ACLY promotes beta-cell survival Correspondence to: James D. Johnson, Ph.D., Associate Professor, Diabetes Research Group, Dept. of Cellular and Physiological Sciences & Dept. of Surgery, University of British Columbia, 5358 Life Sciences Building, 2350 Health Sciences Mall, Vancouver, BC, Canada, V6T 1Z3; Phone: (604)-8227187, Fax: (604) 822-6048; E-mail: jimjohn@interchange.ubc.ca