Degradation of miR-466 d-3 p by JEV NS 3 facilitates viral replication and IL-1 β 2 expression 3 4 Short title : miRNA degradation by NS 3 of JEV 5 6

2 expression 3 4 Short title: miRNA degradation by NS3 of JEV 5 6 Hui Jiang a*, Caiquan Zhao a*, Zhuofang Bai a*, Yanqing Meng a, Tian Qin a, Xiao Wang a, 7 Guojun Wang a, Min Cui b, Jing Ye b, Shengbo Cao b, Guangpeng Li a, †, Yang Yanga, b† 8 9 aThe State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, 10 School of Life Sciences, Inner Mongolia University, Hohhot, 010070, China 11 bThe State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, 12 Huazhong Agricultural University, Wuhan, 430070, China 13 14 *Equal Contributor 15