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Deep brain stimulation versus vagus nerve stimulation in the treatment of therapy-resistant depression: A systematic review and meta-analysis

Lucas Augusto Ayres Ribas,Paulo Henrique Pires de Aguiar,Ana Tereza dos Santos Camargo, Jivago Jordão Camargos Ferreira, Vitor Hernandes Lopes,André Simis, Sylvine Carrondon Cottin,Nevair Galani,Samuel Simis

semanticscholar（2018）

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Abstract
Introduction: “Depression” represents a group of heterogeneous clinical conditions that imposes a serious public health problem. The WHO estimates that depression will be the third leading cause of debilitating diseases by 2030. The established treatment involves antidepressants, psychotherapy, electroconvulsive therapy and transcranial magnetic stimulation. 10 to 20% of patients are depressants resistant to conventional treatments (TRD) and for these, modern psychosurgery is becoming Revista Chilena de Neurocirugía 44: 2018
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