Michaelis complex analog that stabilizes therapeutic lysosomal a-galactosidase A in Fabry disease †

Department of Bio-organic Synthesis, Leiden Einsteinweg 55, 2333 CC Leiden, The leidenuniv.nl Department of Medical Biochemistry, Leide 2333 CC Leiden, The Netherlands Department of Chemistry, York Structural Heslington, York YO10 5DD, UK. E-mail: gid Departament de Qúımica Inorgànica i Orgàn de Qúımica Teòrica i Computacional (IQT Franques 1, 08028 Barcelona, Spain Fundació Catalana de Recerca i Estudis Av 23, 08010 Barcelona, Spain † Electronic supplementary information ( S7, Tables S1 and S2, materials and methods, DFT calculations, crystallograp spectra. See DOI: 10.1039/c9sc03342d Cite this: Chem. Sci., 2019, 10, 9233