Reduces P-Glycoprotein at the Blood – Brain Barrier through the Ubiquitin – Proteasome Pathway

Anika M.S. Hartz,1,2,3 X Yu Zhong,1 Andrea Wolf,3 Harry LeVine, III,1 David S. Miller,4 and Björn Bauer3,5 1Sanders-Brown Center on Aging and 2Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536, 3Department of Pharmacy Practice and Pharmaceutical Sciences, College of Pharmacy, University of Minnesota, Duluth, Minnesota 55812, 4Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, and 5Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536