Výsledky endokrin ních funkcí hypofýzy po trans sfenoidálních operacích afunkčních makroadenomů Results of Endocrine Function after Trans sphenoidal Surgery for Non-functional Pituitary

Aim: The aim of this study was to assess changes to endocrine pituitary function following pituitary macroadenoma surgery and to compare the microscopic and endoscopic techniques. Methods: A study group included patients with nonfunctional pituitary macroadenoma undergoing microscopic or endoscopic transnasal transsphenoidal approach at the Department of Neurosurgery of the University Hospital in Olomouc. All patients underwent neurologic, radiologic and endocrinology examination before and after surgery. All data were retrospectively reviewed and both techniques were statistically compared. Results: A total of 78 patients were included in this study. In patients without preoperative hormonal abnormalities, postoperative defi cit occurred more often in the microscope group (47.4%) compared to endoscopic group (40%) but the diff erence was not statistically signifi cant (p = 0.761). In patients with a preoperative hormonal abnormality, postoperative deterioration of hormonal functions was more frequent again in the microscope-operated (70%) compared to the endoscopic group (21.4%), the diff erence was statistically signifi cant (p = 0.015). Conclusion: In our study, endoscopic technique achieves better postoperative results of pituitary hormonal functions compared to microscopic techniques, particularly in patients with preoperative hormonal abnormality. Článek nebyl podpořen formou grantu, přístrojového vybavení nebo léků. Autoři deklarují, že v souvislosti s předmětem studie nemají žádné komerční zájmy. The authors declare they have no potential confl icts of interest concerning drugs, products, or services used in the study. Redakční rada potvrzuje, že rukopis práce splnil ICMJE kritéria pro publikace zasílané do biomedicínských časopisů. The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers. V. Novák, L. Hrabálek, Z. Fryšák, J. Hoza, C. Hučko, D. Krahulík, J. Machač, M. Vaverka 1 Neurochirurgická klinika LF UP a FN Olomouc 2 III. interní klinika – nefrologická, revmatologická a endokrinologická LF UP a FN Olomouc 3 Otolaryngologická klinika