United States Patent ( 19 ) Porter et al . USOO 6146899 A 11 Patent Number : 6 , 146 , 899 ( 45 ) Date of Patent : Nov . 14 , 2000 54 ) HEIGHT REFERENCING BIOCHEMICAL CASSETTE

William Jones, Patrick, Brown, Michael C. Pirrung, Edward Joseph Sullivan,Maureen T. Cronin, Richard P. Xiaohua C. Hunag, Ann C. Pease,Christopher P. Holmes, Cynthia L. Adams,Charles Y. Cho,Edmund J. Moran, Sara Cherry,James C. Stephans,Stephen P. A. Fodor, Cythia L. Adams, Arathi Sundaram,Jeffrey W. Jacobs, Peter G. Schultz,Alexander B. Chetverin,Fred Russell Kramer, Vivian Wynne Jones,Jeremy R. Kenseth,Marc D. Porter, A. A. Bergman, Curt T. Reimann,Sven Oscarsson, Margot M. E. Snel, Janese C. O'Brien

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Entering the Postgenome Era, Oct. 20, 1995, pp. 368-371. Mark Schena, Dari Shalon, Ronald W. Davis, Patrick Brown; Quantitative Monitoring of Gene Expression Pattern with a Complementary DNA Microaray, 4 pages, Stanford, California. William Bains, Jeffrey L. Fox, Litigation Escalates for Patents on a Chip; 2 Pages David Stipp, Gene Chip Break through, 9 Pages. Stephens PA. Fodor, J. Leighton Read, Michael C. Pirrung, Lubert Stryer, Amy Tsai Lu, Dennis Solas; Light-Directed, Spatially Addressable Parallel Chemical Synthesis; Feb. 15, 1991, pp. 767-773; Palo Alto, California. Ann Caviant Pease, Dennis Solas, Edward J. Sullivan, Maureen T. Cronin, Christopher P. Holmes and Stephen P.A. Fodor; Light-Generated Oligonucleotide Arrays for Rapid DNA Sequence Analysis; May 1994; pp. 5022-5026; Palo Alto, California. Stephen P.A. Fodor, Richard P. Xiaohua C. Hunag, Ann C. Pease, Christopher P. Holmes and Cynthia L. Adams; Mul tiplexed Biochemical Assays with Biological Chips; p. 555. Charles Y. Cho, Edmund J. Moran, Sara R. Cherry, James C. Stephans, Stephen P.A. Fodor, Cythia L. Adams, Arathi Sundaram, Jeffrey W. Jacobs, Peter G. Schultz; An Unnatu ral Biopolymer; Sep. 3, 1993; pp. 1303–1305; Palo Alto, Ca. Alexander B. Chetverin, Fred Russell Kramer; Oligonucle otide Arrays: New Concepts and Possibilities; Nov. 12, 1994; pp. 1093–1099; Moscow Region, Russia and New York, New York. Vivian W. Jones, Jeremy R. Kenseth, and Marc D. Porter; Microminiaturized ImmunoSSayS Using Atomic Force MicroScopy and Compositionally Patterened Antigen Arrays; Feb. 26, 1998; pp. 1233-1241; Ames, Iowa. Arjan P. Quist, Anna A. Bergman, Curt T. Reimann, Sven O. OscarSSon and Bo U.R. Sundqvist, Imaging of Single Anti gens, Antibodies, and Specific Immunocomplex Formation by Scanning Force Microscopy; Jun. 28, 1995, pp. 395-400; Chicago, IL. Oscar H. Willemsen, Margot M.E. Snel, Kees O. van der Werf, art G. de Grooth, Jan Greve, Peter Hinterdorfer, Hermann J. Gruber, Hansgeorg Schindler, Yvette van Kooyk, and Carl G. Figdor; Simultaneous Height and Adhe Sion Imaging of Antibody-Antigen Interactions by Atomic Force Microscopy; Nov. 1998; pp. 2220–2228; The Neth erlands.
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