Heterozygous mutation to Chd 8 causes macrocephaly and widespread 1 alteration of neurodevelopmental transcriptional networks in mouse 2 3

University of California, Davis, Department of Psychiatry and Behavioral Sciences, University 10 of California, Davis, Department of Neurobiology, Physiology and Behavior, The Hospital for 11 Sick Children, Mouse Imaging Centre, Toronto, Canada, University of California, Davis, MIND 12 Institute, School of Medicine, Davis, CA, University of California, Davis, Department of 13 Pathology and Laboratory Medicine, Shriners Hospitals for Children, Institute for Pediatric 14 Regenerative Medicine, Sacramento, CA Lawrence Berkeley National Laboratory, Berkeley, 15 CA, Department of Energy Joint Genome Institute, Walnut Creek, CA, School of Natural 16 Sciences, University of California, Merced, CA. 17