Prevalence of HBV and HCV infections, Bhutan, 2017: Progress and next steps
BMC Infectious Diseases(2020)
摘要
Background Bhutan is committed to eliminating hepatitis B and hepatitis C, though recent baseline estimates of disease burden in the general population are unknown. In 2017, we carried out a biomarker survey in the general population to estimate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) biomarkers to evaluate the impact of immunization and guide further efforts. Methods In 2017, a cross-sectional, population-based, three-stage cluster survey was undertaken of the general population (1–17 and 20+ years of age). We visited households, collected blood specimens and administered a standard questionnaire. Specimens were collected for hepatitis B surface antigen (HBsAg) and hepatitis C virus antibody (anti-HCV) testing. We calculated prevalence of infection and selected characteristics, along with confidence intervals (CIs). Results Of 1372 individuals approached, 1358 (99%) participated. Of those, 1321 (97%) had a specimen tested for HBsAg, and among 1173 enrolled individuals 5 years of age or older, 1150 (98%) individuals were tested for anti-HCV. The prevalence of HBsAg was 2.0% in 775 persons 20 years of age or older (95% CI: 1.0–4.0) and 0.5% in 546 persons 1–17 years of age (95% CI: 0.1–1.8). The prevalence of anti-HCV was 0.3% (95% CI: 0.1–0.8) among persons ≥5 years. Conclusions Universal hepatitis B immunization of infants has resulted in a low prevalence of chronic HBV infection in persons 1–17 years of age and the prevalence of anti-HCV is low among persons aged ≥5 years. Efforts should continue to reach high coverage of the timely birth dose along with completion of the hepatitis B vaccine series. To reduce the chronic liver disease burden among adults, HBV and HCV testing and treatment as indicated might be restricted to pregnant women, blood donors, individuals with chronic liver diseases, and other groups with history of high-risk exposures.
更多查看译文
关键词
Hepatitis B, Epidemiology, Immunization, Prevention of mother to child transmission, Perinatal infections, Evaluation, Survey HBsAg
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要