Transmission Risk of SARS-CoV-2 Among Close Contacts- Results of Case- Contact Tracing

<jats:title xmlns:jats="http://www.ncbi.nlm.nih.gov/JATS1" xmlns="http://www.ncbi.nlm.nih.gov/JATS1" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">Abstract</jats:title> <jats:p xmlns:jats="http://www.ncbi.nlm.nih.gov/JATS1" xmlns="http://www.ncbi.nlm.nih.gov/JATS1" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <jats:bold>Background:</jats:bold> The ongoing outbreak of corona virus Disease-19 (COVID-19) is rapid escalation and global spread.The epidemiological characteristics and particularly its ability to spread in the human population of COVID-19 were uncertainty. We analyzed infection of 2019 novel coronavirus pneumonia (COVID-19) and close contacts in Fuzhou, Fujian Province, and to understand the risk of infection and morbidity in different exposure mode. <jats:bold>Methods:</jats:bold> We investigated cases and their close contacts by face-to –face or telephone interview and conducted laboratory test on nasopharyngeal or oropharyngeal swabs or anal swab for evidence of COVID-19 infection. Information on cases including the epidemiology, expose and laboratory were collected. <jats:bold>Results:</jats:bold> There were 72 patients of COVID-19 and 1 asymptomatic case were confirmed in Fuzhou. A total of 1159 close contacts were traced, the secondary infection rate (SIR) was 2.07% (24/1159), the median of interval was 12 days (rang 2-21 days). In the relationship between close contact and cases, the SIR of old people under care were the highest (28.57% ) than family members (5.52%), medical staff (3.23%), relatives (2.41%) and colleagues / classmates (1.67%), respectively( 2=534.38, P<0.00 ). Among the contact ways, the SIR of Nursing (nursing home) were the highest (28.57% ) than medical care (3.23%), family gathering (2.82%), same building (1.77%) and short talk or handle affairs (1.55%),respectively. The median of incubation period was 5days (rang1-12days). <jats:bold>Conclusions:</jats:bold> The COVID-19 has highly contagious. Timely and strict quarantine should be conducted for close contacts to reduce the possibility of community communication. </jats:p>