Synthesis and biological evaluation of novel isothiazoloquinoline quinone analogues.

Ling Chen,Yuan-Zhu Xie,Zhi-Yong Luo,Li-Jun Liu,Zi-Zheng Zou,Hong-Dou Liu,Fan-Rong Kong, Ying Hao, Jin-Lei Gao,Liu-Liu Wang,Da-You Ma,Su-You Liu

Bioorganic & Medicinal Chemistry Letters（2020）

引用 6|浏览23

暂无评分

摘要

•A series of unique isothiazole-fused quinolinoquinone analogues were synthesized.•Some isothiazoloquinolinoquinones strongly inhibit proliferation of cancer cells and may induce cancer cells apoptosis.•Isothiazoloquinolinoquinones are efficient substrates for NQO1 and induce ROS production in vitro.•Isothiazoloquinolinoquinone inhibits the phosphorylation of STAT3.

查看译文

关键词

Isothiazoloquinoline quinone analogues,Synthesis,Antitumor activities,Structure–activity relationship,NQO1 substrate,ROS production,STAT3 inhibitor

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要