Design, synthesis and biological evaluation of novel 2-alkylidene 19-norcalcitriol analogs.
Bioorganic Chemistry(2020)
Abstract
•Series of 19-norcalcitriol analogs with pegylated 2-alkylidene groups were synthesized.•Pt(II) complexes of two vitamin D analogs were obtained and biologically tested.•Cytotoxic activity of the synthesized 19-norcalcitriol analogs was assessed.
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Key words
19-Norcalcitriol,Vitamin D receptor,Wittig-Horner reaction,Platinum(II) complexes,Drug delivery systems
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