Selective Autophagy Conceals the Enemy: Why Cytotoxic T Cells Don't (MH)C Pancreatic Cancer
MOLECULAR CELL（2020）
Abstract
Cell surface MHC-I can present tumor antigens to CD8(+) T cells. In pancreatic cancer, selective autophagy instead reroutes MHC-I to lysosomes, using the ubiquitin-binding receptor NBR1, precluding T cell recognition. Accordingly, immune clearance of tumors can be facilitated by blocking autophagy.
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