Design of a randomized placebo controlled trial of high dose intravenous thiamine for the prevention of delirium in allogeneic hematopoietic stem cell transplantation

•Thiamine deficiency is a cause of delirium in patients with cancer.•Stem cell transplantation increases risk for thiamine deficiency and delirium.•Preventing delirium may improve quality of life, cognition, and mental health.•Intravenous thiamine may prevent delirium in medically ill, hospitalized patients.