Synthesis, antitumor activity, and molecular docking of (−)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin conjugates
Journal of Asian Natural Products Research(2021)
摘要
Two new (−)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin conjugates (7 and 8) were synthesized and evaluated for biological activity. Compound 8 showed highly potent anticancer activity against A-549 cell line with IC50 of 2.16±1.02 μM, which displayed the highest selectivity index value (SI = 14.5) in A-549 cells. Molecular docking indicated that compound 8 could bind with the active site of Top-II. Therefore, compound 8 might be a promising candidate for further development.
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关键词
Podophyllotixin,EGCG,click reaction,antitumor activity,molecular docking
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