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Solid lipid nanoparticles-mediated enhanced antidepressant activity of duloxetine in lipopolysaccharide-induced depressive model

Isra Rana,Namrah Khan,Muhammad Mohsin Ansari,Fawad Ali Shah,Fakhar ud Din,Sadia Sarwar,Muhammad Imran,Omer Salman Qureshi,Ho-Ik Choi,Cheol-Ho Lee,Jin-Ki Kim,Alam Zeb

Colloids and Surfaces B: Biointerfaces（2020）

Cited 42|Views24
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Abstract
•DLX-SLNs were prepared and optimized using nano-template engineering technique.•DLX-SLNs showed optimum physicochemical properties for efficient brain delivery.•DLX release from SLNs was prolonged for 24 h without initial burst release.•DLX-SLNs significantly reduced LPS-induced depressive behavior in rats.•Plasma and brain BDNF concentrations were significantly enhanced by DLX-SLNs.
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Key words
Duloxetine,Antidepressant activity,Solid lipid nanoparticles,Lipopolysaccharide-induced depression,Brain-derived neurotropic factor
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