Application of synthetic membranes in establishing bio-predictive IVPT for testosterone transdermal gel.

Loqman A Mohamed,Nahid Kamal,Khaled H Elfakhri,Sarah Ibrahim,Muhammad Ashraf,Ahmed S Zidan

International Journal of Pharmaceutics（2020）

引用 5|浏览11

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摘要

A point to point correlation and the exponential function of the fraction absorbed following treatment A with in vitro release obtained using STRAT-M membrane with Flow through diffusion cells (A); and the corresponding predicted and observed concentration–time profiles of testosterone 1.62% testosterone gel utilizing the exponential function (B).

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关键词

IVIVR,Percutaneous absorption,Permeation,Synthetic membranes,Testosterone gel

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