Elevated AT1R Antibody and Morbidity in Patients Bridged to Heart Transplant Using Continuous Flow Left Ventricular Assist Devices
Journal of Cardiac Failure(2020)
摘要
•Angiotensin-II type I receptor antibody (AT1R-Ab) levels increased after left ventricular assist device implantation and remained until heart transplantation.•Increased AT1R-Ab level at time of heart transplant was associated with post-transplant morbidity.•AT1R-Ab levels did not correlate with surrogate markers of systemic inflammation.•Measuring AT1R-Ab levels during left ventricular assist device support could be a useful biomarker to identify LVAD patients at greater risk for poor outcomes after heart transplantation.
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关键词
Heart transplantation,left ventricular assist device,antibody,AT1R antibody,rejection
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