A myelin sheath protein forming its lattice

The formation of a mature, multilayered myelin sheath requires the compaction of lipid bilayers, but the molecular mechanism by which these bilayers condense is an open question. In this issue, Ruskamoet al.find that peripheral myelin protein P2 forms an ordered three-dimensional lattice within model membranes usingEscherichia colipolar lipid liposomes. These data will help to understand the assembly, function, and structure of the myelin sheath.