A cross-platform approach to characterize and screen potential neurovascular unit toxicants

Todd J. Zurlinden,Katerine S. Saili,Nancy C. Baker,Tarja Toimela,Tuula Heinonen,Thomas B. Knudsen

Reproductive Toxicology（2020）

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摘要

•Neurogenic disrupting chemicals impact key events specific to NVU development.•Combining results from multiple cell-based assays characterizes potential NVU hazard.•Grouping endpoints determines chemicals impacting similar NVU key events.•Literature model hypothesizes additional NVU chemicals for investigation.

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关键词

Predictive toxicology,Angiogenesis,Neurogenesis,ToxCast

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