Dysfunctional Immune System Reconstitution After Rituximab Exposure In Utero
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY(2021)
Abstract
Rituximab is an antibody that binds to B-lymphocytes and is increasingly used during pregnancy. As an immunoglobulin G, it will transfer across the placenta. Previous case reports describe a diversity of clinical presentations in neonates born following rituximab exposure in utero. Our case is the first to offer the long-term experience in the care of an infant with severe neutropenia and prolonged profound hypogammaglobulinemia and class-switching B cell defect after in utero rituximab exposure.
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Key words
rituximab, hypogammaglobulinemia, neutropenia, in utero exposure
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