Kir4.1 RNA Interference by In Utero Electroporation Fails to Affect Ictogenesis and Reveals a Possible role of Kir4.1 in Corticogenesis
Neuroscience(2020)
摘要
•In utero RNA interfering efficiently down-regulate Kir 4.1 expression in astrocytes.•The PiggyBac transposon system combined with IUE at E16 fails to alter r K+ buffering.•Focal down-regulation of Kir4.1 reveals a possible role of Kir4.1 on corticogenesis.
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关键词
IUE,NPCs,NGS,PBS,PFA,RNAi,SNPs,TLE
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