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Anti-fibrotic effect of iguratimod on pulmonary fibrosis by inhibiting the fibroblast-to-myofibroblast transition.

Haobo Lin,Chaochen Wu, Fu Zhu,Guangfeng Zhang,Yuesheng Xie,Yang Cui,Guangfu Dong,Xiao Zhang

Advances in Medical Sciences（2020）

Cited 14|Views21
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Abstract
Our results collectively revealed the beneficial effect of IGU on the inhibition of FMT, thus suggesting that it might act as an effective anti-fibrotic agent in preventing the progression of PF.
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Key words
Iguratimod,Fibroblast,TGF-β1,Smad3,Pulmonary fibrosis
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