CXC chemokine receptor 3 antagonist AMG487 shows potent anti-arthritic effects on collagen-induced arthritis by modifying B cell inflammatory profile.
Immunology Letters（2020）
Abstract
•We investigated the effect of AMG487 on the key mediators of RA.•AMG487 treatment downregulated NF-κB signaling in collagen-induced arthritis mice.•AMG487 treatment significantly decreases proinflammatory cytokines in CIA mice.•AMG487-treated mice show upregulation of anti-inflammatory cytokines.•AMG487 exhibits anti-arthritic activity and is a viable therapeutic option for RA.
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Key words
Autoimmune disease,Collagen-induced arthritis,CD19+B cells,CXCR3 antagonist,DBA/1J mice
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