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The effect of olmesartan on aortic intimal thickening after balloon injury through Apelin/APJ.

Yonghong Li, Junjie Guo,Haichu Yu,Jingwei Zhou,Xianming Chu,Bo Hou,Junhua Ge,Tingting Li,Shuo Duan, Hui Xu,Xi Yang

Cardiovascular Pathology（2020）

Cited 2|Views15
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Abstract
•Ang II, AT1, Apelin and APJ mRNA were promoted by vascular balloon injury.•Olmesartan decreased the proliferation of VSMC and the intimal thickening.•Olmesartan inhibits the intimal thickening through activating Apelin/APJ.
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Key words
Ballooninjury,Apelin,APJ,Extracellularsignalregulatedkinase,Olmesartan
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