The effect of olmesartan on aortic intimal thickening after balloon injury through Apelin/APJ.
Cardiovascular Pathology(2020)
Abstract
•Ang II, AT1, Apelin and APJ mRNA were promoted by vascular balloon injury.•Olmesartan decreased the proliferation of VSMC and the intimal thickening.•Olmesartan inhibits the intimal thickening through activating Apelin/APJ.
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Key words
Ballooninjury,Apelin,APJ,Extracellularsignalregulatedkinase,Olmesartan
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