Enhancement of covalent aggregate quantification of protein therapeutics by non-reducing capillary gel electrophoresis using sodium hexadecyl sulfate (CE-SHS).
Journal of Chromatography B（2020）
Abstract
•Capillary Gel Electrophoresis (CGE) can yield apparent, artifact aggregation.•Higher protein-affinity detergents (versus SDS) can reduce CGE-induced aggregation.•Confirm accuracy of optimized CGE data using size exclusion chromatography (SEC).
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Key words
Capillary gel electrophoresis,Chromatography,Ultracentrifugation,Reproducibility,Hydrophobic detergent,Protein therapeutic
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