Protective effect of a polyherbal bioactive fraction in propylthiouracil-induced thyroid toxicity in ratsby modulation of the hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes.

•Hypothyroidism is the most frequent toxic effect of a large variety of chemical compounds.•The polyherbal bioactive fraction exhibited a pro-thyroid effect in hypothyroidic rats.•The polyherbal fraction restored the propylthiouracil-depleted thyroid hormone levels significantly.•The polyherbal fraction may act through multiple mechanisms to exhibit a pro-thyroid effect.