Protective effect of a polyherbal bioactive fraction in propylthiouracil-induced thyroid toxicity in ratsby modulation of the hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes.
Toxicology Reports(2020)
摘要
•Hypothyroidism is the most frequent toxic effect of a large variety of chemical compounds.•The polyherbal bioactive fraction exhibited a pro-thyroid effect in hypothyroidic rats.•The polyherbal fraction restored the propylthiouracil-depleted thyroid hormone levels significantly.•The polyherbal fraction may act through multiple mechanisms to exhibit a pro-thyroid effect.
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AC,CAT,GPx,GR,GSH,HPTLC,HOMA,HDL,Hcy,IR,LPO,LDL,MDA,NIS,PTU,Ru,SOD,T500,T1000,T1500,AE,TAE,T3,T4,TSH,TC,TG,VLDL
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