QUANTITATIVE TOPOGRAPHIC CURVATURE MAPS OF THE POSTERIOR EYE UTILIZING OPTICAL COHERENCE TOMOGRAPHY

Purpose: Deformations of the retina such as staphylomas in myopia or scleral flattening in high intracranial pressure can be challenging to quantify with en face imaging. We describe an optical coherence tomography-based method for the generation of quantitative posterior eye topography maps in normal and pathologic eyes. Methods: Using "whole eye" optical coherence tomography, we corrected for subjects' optical distortions to generate spatially accurate posterior eye optical coherence tomography volumes and created local curvature (K-M, mm(-1)) topography maps for each consented subject. We imaged nine subjects, three normal, two with myopic degeneration, and four with papilledema including one that was imaged longitudinally. Results: Normal subjects mean temporal K-M was 0.0923 mm(-1), nasal K-M was 0.0927 mm(-1), and K-M local variability was 0.0162 mm(-1). In myopic degeneration, subjects K-M local variability was higher at 0.0836 mm(-1). In papilledema subjects nasal K-M was flatter compared with temporal K-M (0.0709 vs. 0.0885 mm(-1)). Mean intrasession K-M repeatability for all subjects was 0.0036 mm(-1). Conclusion: We have developed an optical coherence tomography based method for quantitative posterior eye topography that offers the ability to analyze local curvature with micron scale resolution and offers the potential to help clinicians and researchers characterize subtle, local retinal deformations earlier in patients and follow their development over time.