The antagonistic activity profile of naloxone in μ-opioid receptor agonist-induced psychological dependence.

Atsushi Nakamura,Kana Yasufuku,Shinji Shimada, Hiroyuki Aritomi, Youko Furue,Hiroki Chiba, Mami Muramoto,Kenji Takase,Katsumi Koike, Tomoko Matsumoto,Tomoka Shimada,Ryosuke Watari,Takanobu Matsuzaki,Toshiyuki Asaki,Toshiyuki Kanemasa,Masahide Fujita

Neuroscience Letters（2020）

引用 6|浏览14

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摘要

•Naloxone shows competitive antagonistic activity against μ-opioid receptor agonists.•Oxycodone:naloxone (1:0.5) does not produce conditioned place preference.•An appropriate dose of naloxone can antagonize the psychological dependence on oxycodone.

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关键词

Competitive antagonist,Conditioned place preference,Dopamine release,μ-Opioid receptor agonist,Naloxone

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