Synergistic effect of combined imipenem and photodynamic treatment with the cationic Ir(III) complexes to polypyridine ligand on carbapenem-resistant Klebsiella pneumoniae

Photodiagnosis and Photodynamic Therapy(2020)

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摘要
•The Photodynamic treatment helped to eradicate the MDR bacteria Klebsiella pneumoniae•Photosensitizers based in Ir(III) are useful for aPDI over KPC producer Klebsiella pneumoniae.•Ir(III) PS produces a synergistic effect with imipenem against KPC-producer Klebsiella pneumoniae.•Ir(III) PS produced no cytotoxicity over normal cells but produce light-activated cytotoxicity over tumoral cells.
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关键词
Antibiotic resistance,Photodynamic treatment,Synergy,Klebsiella pneumoniae
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