Effectiveness of Intracameral Moxifloxacin Endophthalmitis Prophylaxis for Trabeculectomy at Aravind Eye Hospitals

Purpose: The effect of intracameral (IC) moxifloxacin prophylaxis after trabeculectomy has not been previously studied. In 2015, Aravind Eye Hospitals (AEH) instituted a standardized IC moxifloxacin policy for trabeculectomy and combined trabeculectomy with cataract extraction, providing a unique opportunity to analyze the effectiveness of IC moxifloxacin in reducing acute postoperative infection after trabeculectomy.Methods: This is a retrospective clinical registry analysis of all patients undergoing either trabeculectomy or trabeculectomy with cataract extraction at AEH from January 2009 to December 2018. Electronic health record data were analyzed before and after policy implementation. Acute (< 6 weeks) postoperative endophthalmitis rates were compared.Results: Overall, 38,900 eyes (Group 1) did not receive IC moxifloxacin while 19,086 eyes (Group 2) did. Combined trabeculectomy with cataract …