Relationship between Vision-related Activity Limitations and Binocular Visual Field Patterns in Retinitis Pigmentosa

Purpose: Retinitis pigmentosa (RP) has characteristic patterns of visual field (VF) loss and is known to reduce perceived quality of life (QoL: activity limitations). There have been no systematic evaluations of the relationship between VF patterns and QoL. Of particular interest was the impact of peripheral islands of vision which are lost as RP progresses.Methods: VFs were measured out to 60-degrees wide with the Humphrey Field Analyzer. Archetypal analysis was used to decompose reliable binocular VFs, finding representative features within the data. Rasch analysis was applied to 12 items of the Vision Function Scale (VFS: Pesudovs et al., 2010) plus an additional 3 driving items, all from the National Eye Institute Visual Function Questionnaire. Data from both sources was available for 604 exams of 194 subjects (20 to 60 years) for up to 7 visits and 6 years of follow-up. A generalized structural equation model …