Should qualitative RT-PCR be used to determine release from isolation of COVID-19 patients?

Karl Krupp,Purnima Madhivanan,Carlos M. Perez-Velez

Journal of Infection（2020）

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摘要

•COVID-19 patients may have persistently positive RT-PCRs for as many as 9 weeks.•Some are being required to continue in isolation until they have negative results.•SARS-CoV-2 qualitative RT-PCR does not distinguish infectious from noninfectious.•Quantitative RT-PCRs and immunoassays are better markers of infectivity period.•Social isolation can have economic, physical, psychological, and social effects.

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关键词

Coronavirus disease 2019 (COVID-19),Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),Polymerase chain reaction (PCR),Social Isolation,Infectivity,Virus Shedding,Socioeconomic Impact,Patient Isolation

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