Identification of cryptotanshinone from Tongmai to inhibit thrombosis in zebrafish via regulating oxidative stress and coagulation cascade

Jian Sheng,Qingfen Meng,Zhenzhong Yang,Jianli Guan,Yu Zhao, Jide Zhang,Yingchao Wang,Lu Zhao,Yi Wang

Phytomedicine（2020）

引用 10|浏览10

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摘要

•Tongmai showed endogenous antithrombotic effect in transgenic zebrafish models.•Tongmai inhibits thrombosis possibly via reducing oxidative stress and coagulation factor II (thrombin) expression.•Cryptotanshinone from Salvia miltiorrhiza Bunge is a major compound with antithrombotic activity.

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关键词

Thrombosis,Zebrafish,Cryptotanshinone,Oxidative stress,Coagulation cascade,Phenylhydrazine

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