Effect of initial management with aflibercept vs laser photocoagulation vs observation on vision loss among patients with diabetic macular edema involving the center of the …
Jama(2019)
Abstract
ImportanceIntravitreous injections of antivascular endothelial growth factor agents are effective for treating diabetic macular edema (DME) involving the center of the macula (center-involved DME [CI-DME]) with visual acuity impairment (20/32 or worse). The best approach to treating patients with CI-DME and good visual acuity (20/25 or better) is unknown.ObjectiveTo compare vision loss at 2 years among eyes initially managed with aflibercept, laser photocoagulation, or observation.Design, Setting, and ParticipantsRandomized clinical trial conducted at 91 US and Canadian sites among 702 adults with type 1 or type 2 diabetes. Participants had 1 study eye with CI-DME and visual acuity of 20/25 or better. The first participant was randomized on November 8, 2013, and the final date of follow-up was September 11, 2018.InterventionsEyes were randomly assigned to 2.0 mg of intravitreous aflibercept (n = 226) as …
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