Correlation Of Immunohistochemical Markers With Disease And Clinical Outcome Measures In Patients With Autoimmune Retinopathy

Purpose: To determine if common immunological markers are significantly different between autoimmune retinopathy (AIR) patients and normal controls and correlate with disease progression in AIR patients.Methods: We enrolled AIR patients seen at the Massachusetts Eye and Ear from February 2016 to February 2018. Normal controls were enrolled from the University of Michigan and had no history of eye disease, autoimmune disease, or cancer. For each participant, a blood sample was tested for immunological markers at the University of Michigan. For AIR patients, blood samples were collected every 6 months. Clinical measurements were recorded at each draw including visual acuity (VA), electroretinogram (ERG) parameters, and Goldmann visual field (GVF) area. Patients were treated with a variety of therapies including antimetabolites and rituximab. We used the Mann Whitney U Test to compare markers …