Insights into high mobility group A (HMGA) proteins from Poaceae family: An in silico approach for studying homologs
Computational Biology and Chemistry(2020)
摘要
•Three major evolutionary clades of Poaceae HMGAs were identified.•Poaceae HMGAs from all the clades, except clade 2 HMGAs, were identified to lack the high-affinity type-I DNA-binding domain.•No. of AT-hook (ATH) motif in Poaceae ranges from 3 to 5.•The C-terminal tail following the last ATH in Poaceae HMGAs is significantly smaller compared to that of mammalian HMGAs.•The length of the C-terminal tail following the last ATH is smallest and highly conserved in clade 2 HMGAs.
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关键词
HMGA,Poaceae,AT-hook,RGRP motifs,H1/H5 domain
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