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Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist

Robert J. Cherney,Lyndon A. M. Cornelius,Anurag Srivastava,Carolyn A. Weigelt,David Marcoux,James J-W Duan,Qing Shi,Douglas G. Batt,Qingjie Liu,Shiuhang Yip,Dauh-Rurng Wu,Max Ruzanov,John Sack,Javed Khan,Jinhong Wang,Melissa Yarde,Mary Ellen Cvijic,Arvind Mathur,Sha Li,David Shuster,Purnima Khandelwal,Virna Borowski,Jenny Xie,Mary Obermeier,Aberra Fura,Kevin Stefanski,Georgia Cornelius,Joseph A. Tino,John E. Macor,Luisa Salter-Cid,Rex Denton,Qihong Zhao,Percy H. Carter,T. G. Murali Dhar

ACS Medicinal Chemistry Letters（2020）

Cited 34|Views100
Key words
ROR gamma t,RORc,inverse agonist,IL-17,IL-23R,psoriasis
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