Abstract# 3050: Association of a TSC2 SNP with sporadic neuroendocrine tumor risk

Background:Neuroendocrine tumors (NET) are rare hormone-secreting cancers arising primarily in the gastrointestinal tract and lung, and are classified into two major subtypes: pancreatic endocrine tumor (PET), and carcinoid tumor. NET may develop in the context of rare inherited genetic syndromes such as multiple endocrine neoplasia 1 or 2. However, the vast majority of NET are thought to be sporadic; in this group, clear genetic risk factors have not been identified. We performed a case-control analysis with a large scale assessment of common genetic variants in known cancer genes to evaluate their potential association with neuroendocrine tumor development. Methods: We evaluated 267 neuroendocrine tumor cases and 329 controls (N= 596, 98% Caucasian), all obtained from Dana-Farber/Harvard Cancer Center Institutions. DNA derived from peripheral blood samples was used to genotype 715 tagging …