Association Of Tyrosine Kinase Inhibitors With Vascular Adverse Events: A Cohort Study Using Pooled Electronic Health Record

MethodsExplorys Enterprise Performance Management (EPM) is a HIPAA-compliant database containing de-identified clinical data on 50 million pts from 26 healthcare networks comprising 360 hospitals since 1999. As this database is HIPAA-compliant, IRB approval was waived by Cleveland Clinic IRB. In this study, we used the EPM database's" power search" tool to create CML cohort and then identified VAE events occurring after TKI initiation using specific temporal relationships. Power searches for data extraction relies on associating clinical informatics standard ontologies that includes Current Procedural Terminology (CPT)(for procedures), International Classification of Diseases 9th edition (ICD-9) and 10th edition (for diagnoses), logical observation identifiers names and codes (LOINC)(for laboratory information), Medical Subject Headings (MeSH)(for medical topics), RxNorm (for pharmacy information …