Methamphetamine induces GSDME-dependent cell death in hippocampal neuronal cells through the endoplasmic reticulum stress pathway.
Brain Research Bulletin（2020）
Abstract
•GSDME is expressed in hippocumpal neuronal cells (HT-22 cells).•METH exposure induces GSDME-dependent cell death in HT-22 cells.•The ER stress signaling pathway is involved in GSDME-dependent cell death induced by METH in HT22 cells.
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Key words
Methamphetamine,Pyroptosis,Endoplasmic reticulum stress,Hippocampal neuronal cells
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