Identification Of Cdc5l As Bridge Gene Between Chronic Obstructive Pulmonary Disease And Lung Adenocarcinoma

EPIGENOMICS(2020)

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摘要
Aim: This study aimed to explore the genetic and epigenetic similarities between chronic obstructive pulmonary disease (COPD) and lung adenocarcinoma (LUAD). Materials & methods: We mainly used Weighted correlation network analysis, protein-protein interaction network and pivot analysis to identify hub modules, bridge regulators, bridge genes and hub-driving genes in both diseases and carried out verifying using external datasets. Results: We identified eight bridge regulators, 19 key molecules in the COPD model and ten key molecules in the LUAD model. Moreover, we validated that CDC5L could be a reliable biomarker in COPD and may regulate cell proliferation and metastasis in LUAD via promoter methylation. Conclusion: Our results might form a theoretical foundation for future study at an epigenetic level.
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关键词
biomarker, cancer metastasis, cancer proliferation, CDC5L, chronic obstructive pulmonary disease, epigenetics, lung adenocarcinoma, methylation, the Cancer Genome Atlas, transcription factors
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