Keratinocyte growth factor ameliorates mycophenolate mofetil-induced intestinal barrier disruption in mice.

Yajun Song,Wengang Hu,Ya Xiao,Yang Li,Xu Wang,Weifeng He,Jingming Hou,Yun Liu,Guangping Liang,Chibing Huang

Molecular Immunology（2020）

Cited 7|Views28

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Abstract

•Mycophenolate mofetil (MMF) induced gastrointestinal disruption and increased intestinal mucosal permeability in a mouse model.•KGF maintained tight junction protein, reversed proliferative inhibition and suppressed the apoptosis of intestinal epithelial cells.•KGF significantly enhanced the proportion of γδ+T intraepithelial lymphocytes.

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Key words

Keratinocyte growth factor,Mycophenolate mofetil,Gastrointestinal side effect,γδ+intraepithelial lymphocyte

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