Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice
Phytomedicine（2020）
Abstract
•EPI inhibits cell growth in MKN-45 and HGC-27 cells•EPI induces p53-dependent mitochondria-associated apoptosis and S phase arrest inMKN-45 cells.•EPI inhibits tumor growth in MKN-45 xenograft nude mice via p53/Bax pathway.
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Key words
Epiberberine,p53,Gastric cancer,Cell cycle arrest,Apoptosis
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