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The Development of a Structurally Distinct Series of BACE1 Inhibitors Via the (Z)-Fluoro-olefin Amide Bioisosteric Replacement.

Michael Frohn,Longbin Liu,Aaron C. Siegmund,Wenyuan Qian,Albert Amegadzie,Ning Chen,Helming Tan,Dean Hickman,Stephen Wood,Paul H. Wen,Michael D. Bartberger,Douglas A. Whittington,Jennifer R. Allen,Matthew P. Bourbeau

Bioorganic & medicinal chemistry letters（2020）

Cited 6|Views37
Key words
Bioisostere,BACE1,(Z)-fluoro-olefin
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